[HTML][HTML] Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor α ligand-binding domain

J Lengqvist, AM De Urquiza, AC Bergman… - Molecular & Cellular …, 2004 - ASBMB
Nuclear receptors (NRs) constitute a large and highly conserved family of ligand-activated
transcription factors that regulate diverse biological processes such as development,
metabolism, and reproduction. As such, NRs have become important drug targets, and the
identification of novel NR ligands is a subject of much interest. The retinoid X receptor (RXR)
belongs to a subfamily of NRs that bind vitamin A metabolites (ie retinoids), including 9-cis-
retinoic acid (9-cis-RA). However, although 9-cis-RA has been described as the natural …