Liver X receptor (LXR)-β regulation in LXRα-deficient mice: implications for therapeutic targeting
EM Quinet, DA Savio, AR Halpern, L Chen… - Molecular …, 2006 - Elsevier
The nuclear receptors liver X receptor (LXR) LXRα and LXRβ are differentially expressed
ligand-activated transcription factors that induce genes controlling cholesterol homeostasis
and lipogenesis. Synthetic ligands for both receptor subtypes activate ATP binding cassette
transporter A1 (ABCA1)-mediated cholesterol metabolism, increase reverse cholesterol
transport, and provide atheroprotection in mice. However, these ligands may also increase
hepatic triglyceride (TG) synthesis via a sterol response element binding protein 1c (SREBP …
ligand-activated transcription factors that induce genes controlling cholesterol homeostasis
and lipogenesis. Synthetic ligands for both receptor subtypes activate ATP binding cassette
transporter A1 (ABCA1)-mediated cholesterol metabolism, increase reverse cholesterol
transport, and provide atheroprotection in mice. However, these ligands may also increase
hepatic triglyceride (TG) synthesis via a sterol response element binding protein 1c (SREBP …
