Background & Aims Adipose tissue (AT)-derived fatty acids (FAs) are utilized for hepatic
triacylglycerol (TG) generation upon fasting. However, their potential impact as signaling
molecules is not established. Herein we examined the role of exogenous AT-derived FAs in
the regulation of hepatic gene expression by investigating mice with a defect in AT-derived
FA supply to the liver. Methods Plasma FA levels, tissue TG hydrolytic activities and lipid
content were determined in mice lacking the lipase co-activator comparative gene …