Inhibition of vascular permeability factor/vascular endothelial growth factor-mediated angiogenesis by the Kruppel-like factor KLF2
R Bhattacharya, S SenBanerjee, Z Lin, S Mir… - Journal of Biological …, 2005 - jbc.org
The Kruppel-like factor KLF2 was recently identified as a novel regulator of endothelial pro-
inflammatory and pro-thrombotic function. Here it is shown that overexpression of KLF2
potently inhibits vascular permeability factor/vascular endothelial growth factor (VEGF-A)-
mediated angiogenesis and tissue edema in the nude ear mouse model of angiogenesis. In
vitro, KLF2 expression retards VEGF-mediated calcium flux, proliferation and induction of
pro-inflammatory factors in endothelial cells. This effect is due to a potent inhibition of …
inflammatory and pro-thrombotic function. Here it is shown that overexpression of KLF2
potently inhibits vascular permeability factor/vascular endothelial growth factor (VEGF-A)-
mediated angiogenesis and tissue edema in the nude ear mouse model of angiogenesis. In
vitro, KLF2 expression retards VEGF-mediated calcium flux, proliferation and induction of
pro-inflammatory factors in endothelial cells. This effect is due to a potent inhibition of …
