NOTCH regulation of the endothelial cell phenotype
JJ Mack, ML Iruela-Arispe - Current opinion in hematology, 2018 - journals.lww.com
Current opinion in hematology, 2018•journals.lww.com
Although it is well accepted that the Notch signaling pathway is essential for vascular
morphogenesis, its contributions to the homeostasis of adult endothelium were uncovered
only recently. Furthermore, its exquisite regulation by flow and impressive interface with
multiple signaling pathways indicates that Notch is at the center of a highly interactive web
that integrates both physical and chemical signals to ensure vascular stability.
morphogenesis, its contributions to the homeostasis of adult endothelium were uncovered
only recently. Furthermore, its exquisite regulation by flow and impressive interface with
multiple signaling pathways indicates that Notch is at the center of a highly interactive web
that integrates both physical and chemical signals to ensure vascular stability.
Summary
Although it is well accepted that the Notch signaling pathway is essential for vascular morphogenesis, its contributions to the homeostasis of adult endothelium were uncovered only recently. Furthermore, its exquisite regulation by flow and impressive interface with multiple signaling pathways indicates that Notch is at the center of a highly interactive web that integrates both physical and chemical signals to ensure vascular stability.
Lippincott Williams & Wilkins