Standardization of platelet‐derived microparticle enumeration by flow cytometry with calibrated beads: results of the International Society on Thrombosis and …
R Lacroix, S Robert, P Poncelet, RS Kasthuri… - Journal of Thrombosis …, 2010 - jthjournal.org
Microparticles (MPs) are sub-micrometer sized vesicles released from cell membranes in
response to activation or apoptosis [1]. MPs originating from several cell sources have been
described in human plasma. Among them, plateletderived MPs (PMPs) are believed to
account for the majority of circulating MPs in healthy subjects [2]. Their levels are increased
in several prothrombotic and inflammatory disorders [1]. In these clinical settings, PMP
counts may be useful for identifying patients at risk for vascular disorders and for monitoring …
response to activation or apoptosis [1]. MPs originating from several cell sources have been
described in human plasma. Among them, plateletderived MPs (PMPs) are believed to
account for the majority of circulating MPs in healthy subjects [2]. Their levels are increased
in several prothrombotic and inflammatory disorders [1]. In these clinical settings, PMP
counts may be useful for identifying patients at risk for vascular disorders and for monitoring …