[HTML][HTML] Quantitative temporal viromics of an inducible HIV-1 model yields insight to global host targets and phospho-dynamics associated with protein Vpr
The mechanisms by which human immunodeficiency virus (HIV) circumvents and coopts
cellular machinery to replicate and persist in cells are not fully understood. HIV accessory
proteins play key roles in the HIV life cycle by altering host pathways that are often
dependent on post-translational modifications (PTMs). Thus, the identification of HIV
accessory protein host targets and their PTM status is critical to fully understand how HIV
invades, avoids detection and replicates to spread infection. To date, a comprehensive …
cellular machinery to replicate and persist in cells are not fully understood. HIV accessory
proteins play key roles in the HIV life cycle by altering host pathways that are often
dependent on post-translational modifications (PTMs). Thus, the identification of HIV
accessory protein host targets and their PTM status is critical to fully understand how HIV
invades, avoids detection and replicates to spread infection. To date, a comprehensive …
