The canonical Wnt/β-catenin signaling pathway stimulates herpes simplex virus 1 productive infection
L Zhu, C Jones - Virus research, 2018 - Elsevier
The ability of herpes simplex virus 1 (HSV-1) to replicate efficiently in differentiated cells is
regulated by cellular factors that stimulate viral gene expression, cell survival, and viral
morphogenesis. Activation of the canonical Wnt signaling pathway generally increases β-
catenin protein levels, cell survival, and growth in dividing cells suggesting this important
signaling pathway regulates productive infection. In this study, we demonstrated that a β-
catenin specific small molecule inhibitor (iCRT14) reduced HSV-1 titers approximately 10 …
regulated by cellular factors that stimulate viral gene expression, cell survival, and viral
morphogenesis. Activation of the canonical Wnt signaling pathway generally increases β-
catenin protein levels, cell survival, and growth in dividing cells suggesting this important
signaling pathway regulates productive infection. In this study, we demonstrated that a β-
catenin specific small molecule inhibitor (iCRT14) reduced HSV-1 titers approximately 10 …