[HTML][HTML] Role of intrinsic protein disorder in the function and interactions of the transcriptional coactivators CREB-binding protein (CBP) and p300
HJ Dyson, PE Wright - Journal of Biological Chemistry, 2016 - ASBMB
The transcriptional coactivators CREB-binding protein (CBP) and p300 undergo a
particularly rich set of interactions with disordered and partly ordered partners, as a part of
their ubiquitous role in facilitating transcription of genes. CBP and p300 contain a number of
small structured domains that provide scaffolds for the interaction of disordered
transactivation domains from a wide variety of partners, including p53, hypoxia-inducible
factor 1α (HIF-1α), NF-κB, and STAT proteins, and are the targets for the interactions of …
particularly rich set of interactions with disordered and partly ordered partners, as a part of
their ubiquitous role in facilitating transcription of genes. CBP and p300 contain a number of
small structured domains that provide scaffolds for the interaction of disordered
transactivation domains from a wide variety of partners, including p53, hypoxia-inducible
factor 1α (HIF-1α), NF-κB, and STAT proteins, and are the targets for the interactions of …