[HTML][HTML] Inflammation and insulin resistance

SE Shoelson, J Lee, AB Goldfine - The Journal of clinical …, 2006 - Am Soc Clin Investig
The Journal of clinical investigation, 2006Am Soc Clin Investig
Over a hundred years ago, high doses of salicylates were shown to lower glucose levels in
diabetic patients. This should have been an important clue to link inflammation to the
pathogenesis of type 2 diabetes (T2D), but the antihyperglycemic and antiinflammatory
effects of salicylates were not connected to the pathogenesis of insulin resistance until
recently. Together with the discovery of an important role for tissue macrophages, these new
findings are helping to reshape thinking about how obesity increases the risk for developing …
Over a hundred years ago, high doses of salicylates were shown to lower glucose levels in diabetic patients. This should have been an important clue to link inflammation to the pathogenesis of type 2 diabetes (T2D), but the antihyperglycemic and antiinflammatory effects of salicylates were not connected to the pathogenesis of insulin resistance until recently. Together with the discovery of an important role for tissue macrophages, these new findings are helping to reshape thinking about how obesity increases the risk for developing T2D and the metabolic syndrome. The evolving concept of insulin resistance and T2D as having immunological components and an improving picture of how inflammation modulates metabolism provide new opportunities for using antiinflammatory strategies to correct the metabolic consequences of excess adiposity.
The Journal of Clinical Investigation