Brd4: tethering, segregation and beyond
AA McBride, MG McPhillips, JG Oliveira - Trends in microbiology, 2004 - cell.com
AA McBride, MG McPhillips, JG Oliveira
Trends in microbiology, 2004•cell.comPapillomaviruses segregate their genomes in dividing cells by tethering them to mitotic
chromosomes via the viral E2 protein. A recent report has shown that this interaction is
mediated by the cellular bromodomain protein Brd4. This discovery provides new insight
into the mechanism of viral genome segregation and raises many exciting questions about
the regulation and nature of the interaction of this complex with mitotic chromosomes.
chromosomes via the viral E2 protein. A recent report has shown that this interaction is
mediated by the cellular bromodomain protein Brd4. This discovery provides new insight
into the mechanism of viral genome segregation and raises many exciting questions about
the regulation and nature of the interaction of this complex with mitotic chromosomes.
Papillomaviruses segregate their genomes in dividing cells by tethering them to mitotic chromosomes via the viral E2 protein. A recent report has shown that this interaction is mediated by the cellular bromodomain protein Brd4. This discovery provides new insight into the mechanism of viral genome segregation and raises many exciting questions about the regulation and nature of the interaction of this complex with mitotic chromosomes.
cell.com