[HTML][HTML] Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal …
Adipocyte fatty acid-binding protein (A-FABP) has emerged as an important mediator of
inflammation in macrophages. Macrophage-selective ablation of A-FABP alone is sufficient
to prevent the development of high cholesterol diet-induced atherosclerosis in apoE-
deficient mice. However, the precise mechanisms whereby A-FABP modulates inflammation
remain elusive. Here, we report that A-FABP forms a finely tuned positive loop between JNK
and activator protein-1 (AP-1) to exacerbate lipopolysaccharide (LPS)-induced inflammatory …
inflammation in macrophages. Macrophage-selective ablation of A-FABP alone is sufficient
to prevent the development of high cholesterol diet-induced atherosclerosis in apoE-
deficient mice. However, the precise mechanisms whereby A-FABP modulates inflammation
remain elusive. Here, we report that A-FABP forms a finely tuned positive loop between JNK
and activator protein-1 (AP-1) to exacerbate lipopolysaccharide (LPS)-induced inflammatory …