Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation
EC Lai - Nature genetics, 2002 - nature.com
Nature genetics, 2002•nature.com
Micro RNAs are a large family of noncoding RNAs of 21–22 nucleotides whose functions are
generally unknown. Here a large subset of Drosophila micro RNAs is shown to be perfectly
complementary to several classes of sequence motif previously demonstrated to mediate
negative post-transcriptional regulation. These findings suggest a more general role for
micro RNAs in gene regulation through the formation of RNA duplexes.
generally unknown. Here a large subset of Drosophila micro RNAs is shown to be perfectly
complementary to several classes of sequence motif previously demonstrated to mediate
negative post-transcriptional regulation. These findings suggest a more general role for
micro RNAs in gene regulation through the formation of RNA duplexes.
Abstract
Micro RNAs are a large family of noncoding RNAs of 21–22 nucleotides whose functions are generally unknown. Here a large subset of Drosophila micro RNAs is shown to be perfectly complementary to several classes of sequence motif previously demonstrated to mediate negative post-transcriptional regulation. These findings suggest a more general role for micro RNAs in gene regulation through the formation of RNA duplexes.
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