[HTML][HTML] Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons
V Gielen, A Sykes, J Zhu, B Chan, J Macintyre… - Journal of Allergy and …, 2015 - Elsevier
Background Rhinovirus infections are the dominant cause of asthma exacerbations, and
deficient virus induction of IFN-α/β/λ in asthmatic patients is important in asthma
exacerbation pathogenesis. Mechanisms causing this interferon deficiency in asthmatic
patients are unknown. Objective We sought to investigate the expression of suppressor of
cytokine signaling (SOCS) 1 in tissues from asthmatic patients and its possible role in
impaired virus-induced interferon induction in these patients. Methods We assessed SOCS1 …
deficient virus induction of IFN-α/β/λ in asthmatic patients is important in asthma
exacerbation pathogenesis. Mechanisms causing this interferon deficiency in asthmatic
patients are unknown. Objective We sought to investigate the expression of suppressor of
cytokine signaling (SOCS) 1 in tissues from asthmatic patients and its possible role in
impaired virus-induced interferon induction in these patients. Methods We assessed SOCS1 …
