Inhibition of house dust mite–induced allergic airways disease by antagonism of microRNA-145 is comparable to glucocorticoid treatment
Background Glucocorticoids are used as mainstay therapy for asthma, but some patients
remain resistant to therapy. MicroRNAs (miRNAs) are important regulators of the immune
system by promoting the catabolism of their target transcripts as well as attenuating their
translation. The role of miRNA in regulating allergic inflammation remains largely unknown.
Blocking miRNA function may provide a new nonsteroidal anti-inflammatory approach to
treatment. Objectives To (1) determine the role of specific miRNAs in the regulation of …
remain resistant to therapy. MicroRNAs (miRNAs) are important regulators of the immune
system by promoting the catabolism of their target transcripts as well as attenuating their
translation. The role of miRNA in regulating allergic inflammation remains largely unknown.
Blocking miRNA function may provide a new nonsteroidal anti-inflammatory approach to
treatment. Objectives To (1) determine the role of specific miRNAs in the regulation of …