Effects of glucocorticoids on endogenous and transcellular metabolism of eicosanoids in asthma
I Vachier, C Chavis, M Majori, M Farce… - Journal of allergy and …, 2001 - Elsevier
Background: Human blood polymorphonuclear cells, which biosynthesize eicosanoids from
the 5-lipoxygenase (5-LO) pathway, are likely to be involved in asthma, in which
glucocorticoids represent the first line of therapy. Their effects on leukotriene release after a
short course of treatment, which have been reported in several studies, are controversial.
Objective: We sought to investigate whether long-term oral glucocorticoids inhibit lipid
mediators from the 5-LO pathway. Methods: Twelve normal control subjects, 29 asthmatic …
the 5-lipoxygenase (5-LO) pathway, are likely to be involved in asthma, in which
glucocorticoids represent the first line of therapy. Their effects on leukotriene release after a
short course of treatment, which have been reported in several studies, are controversial.
Objective: We sought to investigate whether long-term oral glucocorticoids inhibit lipid
mediators from the 5-LO pathway. Methods: Twelve normal control subjects, 29 asthmatic …
