Current asthma therapy is based on the use of adrenergic bronchodilator and anti-
inflammatory drugs the specificity, efficacy, duration of action, and safety of which have been
derived through classical pharmacology and medicinal chemistry. That asthma is a TH2-type
inflammatory disorder frequently associated with atopy and allergic comorbidities has led to
a concentrated effort to find treatments that act selectively on this pathway. A systematic
literature review was undertaken, as well as a review of the Web site Clinicaltrials. gov for …