Repression of an interleukin-4-responsive promoter requires cooperative BCL-6 function
MB Harris, J Mostecki, PB Rothman - Journal of Biological Chemistry, 2005 - jbc.org
BCL-6 functions as a potent transcriptional repressor that binds with specificity to DNA
elements bearing marked similarity to STAT recognition sequences. Previous studies have
demonstrated that BCL-6 and Stat6 can both bind and regulate the Iϵ promoter that controls
immunoglobulin heavy chain class switching to IgE. Examination of BCL-6−/-and BCL-6−/-
Stat6−/-mice has demonstrated that BCL-6 is a repressor of IgE and that Stat6 is still
required for the interleukin-4 (IL-4) induction of class switching to IgE in B cells lacking BCL …
elements bearing marked similarity to STAT recognition sequences. Previous studies have
demonstrated that BCL-6 and Stat6 can both bind and regulate the Iϵ promoter that controls
immunoglobulin heavy chain class switching to IgE. Examination of BCL-6−/-and BCL-6−/-
Stat6−/-mice has demonstrated that BCL-6 is a repressor of IgE and that Stat6 is still
required for the interleukin-4 (IL-4) induction of class switching to IgE in B cells lacking BCL …
