There are significant differences in the pharmacokinetic properties of inhaled corticosteroids
currently used in medical practice. All are rapidly cleared from the body but they show
varying levels of oral bioavailability and more importantly variation in the rate of absorption
after inhalation. Oral bioavailability is lowest for fluticasone propionate, indicating a low
potential for unwanted systemic corticosteroid effects. Mathematical modeling has shown
pulmonary residence times to be longest for fluticasone propionate and triamcinolone …