Resolution of inflammation and the return of tissues to homeostasis are essential. Efforts to
identify molecular events governing termination of self-limited inflammation uncovered
pathways in resolving exudates that actively generate, from essential omega fatty acids, new
families of local-acting mediators. These chemical mediator families, termed resolvins and
protectins, are potent stereoselective agonists that control the duration and magnitude of
inflammation, joining the lipoxins as signals in resolution. This review examines the …