Aminoglycoside toxicity in neonates: something to worry about?
A Kent, MA Turner, M Sharland… - Expert review of anti …, 2014 - Taylor & Francis
Expert review of anti-infective therapy, 2014•Taylor & Francis
Toxicity has limited the use of aminoglycosides and adult studies report high rates of both
ototoxicity and nephrotoxicity. Conversely paediatric studies have shown lower rates and
extended interval dosing may have reduced toxicity further. We review the animal and
human evidence for aminoglycoside toxicity in neonates including mechanisms,
measurement and rates of toxicity; and differences between aminoglycosides and dosing
regimens. We discuss genetic susceptibility and the impact of other synergistic effects.
ototoxicity and nephrotoxicity. Conversely paediatric studies have shown lower rates and
extended interval dosing may have reduced toxicity further. We review the animal and
human evidence for aminoglycoside toxicity in neonates including mechanisms,
measurement and rates of toxicity; and differences between aminoglycosides and dosing
regimens. We discuss genetic susceptibility and the impact of other synergistic effects.
Toxicity has limited the use of aminoglycosides and adult studies report high rates of both ototoxicity and nephrotoxicity. Conversely paediatric studies have shown lower rates and extended interval dosing may have reduced toxicity further. We review the animal and human evidence for aminoglycoside toxicity in neonates including mechanisms, measurement and rates of toxicity; and differences between aminoglycosides and dosing regimens. We discuss genetic susceptibility and the impact of other synergistic effects.
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