Increase in activity during calorie restriction requires Sirt1
D Chen, AD Steele, S Lindquist, L Guarente - Science, 2005 - science.org
D Chen, AD Steele, S Lindquist, L Guarente
Science, 2005•science.orgSir2 (silent information regulator 2) is a nicotinamide adenine dinucletide‐dependent
deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In
mammals, calorie restriction induces a complex pattern of physiological and behavioral
changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the
induction of a phenotype by calorie restriction in mice.
deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In
mammals, calorie restriction induces a complex pattern of physiological and behavioral
changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the
induction of a phenotype by calorie restriction in mice.
Sir2 (silent information regulator 2) is a nicotinamide adenine dinucletide‐dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.
AAAS