[HTML][HTML] Histone deacetylase SIRT1 controls proliferation, circadian rhythm, and lipid metabolism during liver regeneration in mice
MM Bellet, S Masri, G Astarita, P Sassone-Corsi… - Journal of Biological …, 2016 - ASBMB
Liver regeneration offers a distinctive opportunity to study cell proliferation in vivo.
Mammalian silent information regulator 1 (SIRT1), a NAD+-dependent histone deacetylase,
is an important regulator of various cellular processes, including proliferation, metabolism,
and circadian rhythms. In the liver, SIRT1 coordinates the circadian oscillation of clock-
controlled genes, including genes that encode enzymes involved in metabolic pathways. We
performed partial hepatectomy in WT and liver-specific Sirt1-deficient mice and analyzed the …
Mammalian silent information regulator 1 (SIRT1), a NAD+-dependent histone deacetylase,
is an important regulator of various cellular processes, including proliferation, metabolism,
and circadian rhythms. In the liver, SIRT1 coordinates the circadian oscillation of clock-
controlled genes, including genes that encode enzymes involved in metabolic pathways. We
performed partial hepatectomy in WT and liver-specific Sirt1-deficient mice and analyzed the …