[PDF][PDF] Epidemic pertussis and acellular pertussis vaccine failure in the 21st century
JD Cherry - Pediatrics, 2015 - escholarship.org
JD Cherry
Pediatrics, 2015•escholarship.orgIn this issue of Pediatrics Acosta et al1 present a tetanus toxoid, reduced diphtheria toxoid,
and acellular pertussis, adsorbed (Tdap) vaccine effectiveness study in adolescents in
Washington State during the first 6 months of 2012. Their findings support the previous Tdap
effectiveness data from Wisconsin. 2 The duration of Tdap effectiveness is disappointing,
particularly because case-control studies tend to inflate efficacy. 3 In 4 recent publications
(including 1 article in Pediatrics) I have discussed epidemic pertussis and why vaccines fail …
and acellular pertussis, adsorbed (Tdap) vaccine effectiveness study in adolescents in
Washington State during the first 6 months of 2012. Their findings support the previous Tdap
effectiveness data from Wisconsin. 2 The duration of Tdap effectiveness is disappointing,
particularly because case-control studies tend to inflate efficacy. 3 In 4 recent publications
(including 1 article in Pediatrics) I have discussed epidemic pertussis and why vaccines fail …
In this issue of Pediatrics Acosta et al1 present a tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis, adsorbed (Tdap) vaccine effectiveness study in adolescents in Washington State during the first 6 months of 2012. Their findings support the previous Tdap effectiveness data from Wisconsin. 2 The duration of Tdap effectiveness is disappointing, particularly because case-control studies tend to inflate efficacy. 3
In 4 recent publications (including 1 article in Pediatrics) I have discussed epidemic pertussis and why vaccines fail. 4–7 Before discussing why Tdap vaccine effectiveness wanes so rapidly, it seems worthwhile to discuss how rapidly protection wanes after a natural infection in the pre-Tdap era and to take a realistic look at the resurgence of pertussis.
escholarship.org