[HTML][HTML] Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus-associated malignancies
J Strauss, ME Gatti-Mays, BC Cho, A Hill… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Journal for immunotherapy of cancer, 2020•ncbi.nlm.nih.gov
Background Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the
extracellular domain of transforming growth factor (TGF)-βRII (a TGF-β 'trap') fused to a
human IgG1 mAb blocking programmed cell death ligand 1. This is the largest analysis of
patients with advanced, pretreated human papillomavirus (HPV)-associated malignancies
treated with bintrafusp alfa. Methods
extracellular domain of transforming growth factor (TGF)-βRII (a TGF-β 'trap') fused to a
human IgG1 mAb blocking programmed cell death ligand 1. This is the largest analysis of
patients with advanced, pretreated human papillomavirus (HPV)-associated malignancies
treated with bintrafusp alfa. Methods
Abstract
Background
Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of transforming growth factor (TGF)-βRII (a TGF-β ‘trap’) fused to a human IgG1 mAb blocking programmed cell death ligand 1. This is the largest analysis of patients with advanced, pretreated human papillomavirus (HPV)-associated malignancies treated with bintrafusp alfa.
Methods
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