[HTML][HTML] Adenoviruses isolated from wild gorillas are closely related to human species C viruses
MV Duncan, MR Cranfield, H Torano, HM Kuete… - Virology, 2013 - Elsevier
MV Duncan, MR Cranfield, H Torano, HM Kuete, GP Lee, A Glenn, JT Bruder, D Rangel…
Virology, 2013•ElsevierWe have isolated and cultured three distinct adenoviruses from wild gorillas. Phylogenetic
analysis grouped the viruses with human adenovirus species C based on DNA polymerase,
hexon, and E4ORF6 genes. The three wild gorilla adenoviruses clustered with the other
species C captive gorilla adenoviruses, forming a branch separate from human and
chimpanzee/bonobo adenoviruses. Animal sera to the three newly isolated viruses did not
cross-neutralize, demonstrating serological distinctiveness. The human adenovirus 5 fiber …
analysis grouped the viruses with human adenovirus species C based on DNA polymerase,
hexon, and E4ORF6 genes. The three wild gorilla adenoviruses clustered with the other
species C captive gorilla adenoviruses, forming a branch separate from human and
chimpanzee/bonobo adenoviruses. Animal sera to the three newly isolated viruses did not
cross-neutralize, demonstrating serological distinctiveness. The human adenovirus 5 fiber …
Abstract
We have isolated and cultured three distinct adenoviruses from wild gorillas. Phylogenetic analysis grouped the viruses with human adenovirus species C based on DNA polymerase, hexon, and E4ORF6 genes. The three wild gorilla adenoviruses clustered with the other species C captive gorilla adenoviruses, forming a branch separate from human and chimpanzee/bonobo adenoviruses. Animal sera to the three newly isolated viruses did not cross-neutralize, demonstrating serological distinctiveness. The human adenovirus 5 fiber knob blocked infection, suggesting use of the Coxsackie and Adenovirus Receptor. These viruses may provide viral vectors with properties distinct from chimpanzee adenovirus and human adenovirus vectors.
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