Angiopoietins (Angs) are endothelium-selective ligands that exert most of their actions
through the Tie-2 receptor. It is widely accepted that Ang-1 promotes the structural integrity
of blood vessels and exhibits anti-inflammatory properties. In contrast, the role of Ang-2
remains less clear because it has been shown to behave as a Tie-2 agonist or antagonist
under different experimental conditions. To define the role of Ang-2 in acute inflammation,
we studied the effects of recombinant Ang-2 administration in vivo. We show herein that Ang …