Claudin-5 levels are reduced from multiple cell types in human failing hearts and are associated with mislocalization of ephrin-B1
Claudin-5 is transcriptionally downregulated resulting in dramatically reduced protein levels
in human heart failure. Studies in mice have demonstrated that reduced claudin-5 levels
occur prior to cardiac damage and far before reduced whole heart function. Therefore,
claudin-5 may be a useful early therapeutic target for human heart failure. However, the cell
types in which claudin-5 is localized in human heart and from which claudin-5 is reduced in
heart failure is not known. The recent identification of claudin-5's interaction with ephrin-B1 …
in human heart failure. Studies in mice have demonstrated that reduced claudin-5 levels
occur prior to cardiac damage and far before reduced whole heart function. Therefore,
claudin-5 may be a useful early therapeutic target for human heart failure. However, the cell
types in which claudin-5 is localized in human heart and from which claudin-5 is reduced in
heart failure is not known. The recent identification of claudin-5's interaction with ephrin-B1 …