Does reduced zona pellucida binding protein 2 (ZPBP2) expression on chromosome 17q21 protect against asthma?
M Miller, C Vuong, MF Garcia, P Rosenthal… - Journal of Allergy and …, 2018 - jacionline.org
ZPBP2 is highly expressed in sperm, where it is known to be required for formation of mature
spermatozoa. 9 During fertilization, ZPBP2 binds to the zona pellucida, which surrounds the
oocyte to allow sperm penetration. 9 Because ZPBP2 is highly expressed in sperm, whether
it could also be linked to expression in structural, immune, or inflammatory cells pertinent to
the pathogenesis of asthma in male and female subjects is at present uncertain. Therefore
we initially examined whether Zpbp2 was expressed in the lungs of wild-type (WT) mice …
spermatozoa. 9 During fertilization, ZPBP2 binds to the zona pellucida, which surrounds the
oocyte to allow sperm penetration. 9 Because ZPBP2 is highly expressed in sperm, whether
it could also be linked to expression in structural, immune, or inflammatory cells pertinent to
the pathogenesis of asthma in male and female subjects is at present uncertain. Therefore
we initially examined whether Zpbp2 was expressed in the lungs of wild-type (WT) mice …