Intracellular Ca2+-transport ATPases exert a pivotal role in the endoplasmic reticulum and in
the compartments of the cellular secretory pathway by maintaining a sufficiently high
lumenal Ca2+ (and Mn2+) concentration in these compartments required for an impressive
number of vastly different cell functions. At the same time this lumenal Ca2+ represents a
store of releasable activator Ca2+ controlling an equally impressive number of cytosolic
functions. This review mainly focuses on the different Ca2+-transport ATPases found in the …