[HTML][HTML] Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium
T Suzuki, N Yoshinaga, S Tanabe - Journal of Biological Chemistry, 2011 - ASBMB
In inflammatory bowel diseases (IBD), intestinal barrier function is impaired as a result of
deteriorations in epithelial tight junction (TJ) structure. IL-6, a pleiotropic cytokine, is elevated
in IBD patients, although the role of IL-6 in barrier function remains unknown. We present
evidence that IL-6 increases TJ permeability by stimulating the expression of channel-
forming claudin-2, which is required for increased caudal-related homeobox (Cdx) 2 through
the MEK/ERK and PI3K pathways in intestinal epithelial cells. IL-6 increases the cation …
deteriorations in epithelial tight junction (TJ) structure. IL-6, a pleiotropic cytokine, is elevated
in IBD patients, although the role of IL-6 in barrier function remains unknown. We present
evidence that IL-6 increases TJ permeability by stimulating the expression of channel-
forming claudin-2, which is required for increased caudal-related homeobox (Cdx) 2 through
the MEK/ERK and PI3K pathways in intestinal epithelial cells. IL-6 increases the cation …