Induction and chemotherapeutic response of two transplantable ductal adenocarcinomas of the pancreas in C57BL/6 mice

TH Corbett, BJ Roberts, WR Leopold, JC Peckham… - Cancer research, 1984 - AACR
TH Corbett, BJ Roberts, WR Leopold, JC Peckham, LJ Wilkoff, DP Griswold Jr…
Cancer research, 1984AACR
Following implant of cotton thread-carrying 3-methyl-cholanthrene into the pancreas tissue
of 90 C57BL/6 and 60 BALB/c mice, 13 developed ductal adenocarcinomas. Two of these
tumors, both of C57BL/6 origin (Panc 02 and 03), were established in serial sc transplant.
Panc 02 was treated with 37 different anticancer drugs representing all of the chemical and
functional classess of clinically useful anticancer agents including alkylating agents,
antimetabolites, agents that bind to or cause scission of DNA, and others that inhibit mitosis …
Abstract
Following implant of cotton thread-carrying 3-methyl-cholanthrene into the pancreas tissue of 90 C57BL/6 and 60 BALB/c mice, 13 developed ductal adenocarcinomas. Two of these tumors, both of C57BL/6 origin (Panc 02 and 03), were established in serial s.c. transplant. Panc 02 was treated with 37 different anticancer drugs representing all of the chemical and functional classess of clinically useful anticancer agents including alkylating agents, antimetabolites, agents that bind to or cause scission of DNA, and others that inhibit mitosis or inhibit protein synthesis. When drug treatment was started within 3 to 4 days after tumor implant, Panc 02 showed only limited response to treatment with two nitrosoureas, [N′-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea, monohydrochloride and N-(2-chloroethyl)-N′-(2,6-dioxo-3-piperdinyl)-N-nitrosoureal)], and N-phosphonacetyl-l-aspartate. Drug response of Panc 03 was determined only with Adriamycin, 5-fluorouracil, cyclophosphamide, cis-(SP-4-2)-diamminedichloroplatinum, or N,N′-bis(2-chloroethyl)-N-nitrosourea. When drug treatment was started 3 days after tumor implant, high cure rates were obtained with Adriamycin treatment, and limited therapeutic responses were seen to treatment with cis-diamminedichloroplatinum or cyclophosphamide.
A comparison of the biological characteristics and drug responsiveness of Panc 02 and Panc 03 with those of a number of other transplantable tumors of mice is reported.
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