[HTML][HTML] Repression of cyclin D1 expression is necessary for the maintenance of cell cycle exit in adult mammalian cardiomyocytes
S Tane, M Kubota, H Okayama, A Ikenishi… - Journal of Biological …, 2014 - ASBMB
The hearts of neonatal mice and adult zebrafish can regenerate after injury through
proliferation of preexisting cardiomyocytes. However, adult mammals are not capable of
cardiac regeneration because almost all cardiomyocytes exit their cell cycle. Exactly how the
cell cycle exit is maintained and how many adult cardiomyocytes have the potential to
reenter the cell cycle are unknown. The expression and activation levels of main cyclin-
cyclin-dependent kinase (CDK) complexes are extremely low or undetectable at adult …
proliferation of preexisting cardiomyocytes. However, adult mammals are not capable of
cardiac regeneration because almost all cardiomyocytes exit their cell cycle. Exactly how the
cell cycle exit is maintained and how many adult cardiomyocytes have the potential to
reenter the cell cycle are unknown. The expression and activation levels of main cyclin-
cyclin-dependent kinase (CDK) complexes are extremely low or undetectable at adult …