Comprehensive and integrated genomic characterization of adult soft tissue sarcomas
Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic
diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue
sarcomas representing 6 major types. Along with novel insights into the biology of individual
sarcoma types, we report three overarching findings:(1) unlike most epithelial malignancies,
these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-
number changes, with low mutational loads and only a few genes (TP53, ATRX, RB1) highly …
diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue
sarcomas representing 6 major types. Along with novel insights into the biology of individual
sarcoma types, we report three overarching findings:(1) unlike most epithelial malignancies,
these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-
number changes, with low mutational loads and only a few genes (TP53, ATRX, RB1) highly …
[PDF][PDF] Comprehensive and integrated genomic characterization of adult soft tissue sarcomas
A Abeshouse, C Adebamowo, SN Adebamowo… - Cell, 2017 - cell.com
Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic
diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue
sarcomas representing 6 major types. Along with novel insights into the biology of individual
sarcoma types, we report three overarching findings:(1) unlike most epithelial malignancies,
these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-
number changes, with low mutational loads and only a few genes (TP53, ATRX, RB1) highly …
diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue
sarcomas representing 6 major types. Along with novel insights into the biology of individual
sarcoma types, we report three overarching findings:(1) unlike most epithelial malignancies,
these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-
number changes, with low mutational loads and only a few genes (TP53, ATRX, RB1) highly …