[HTML][HTML] Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon
Background The mechanisms underlying altered susceptibility and propensity to severe
Coronavirus disease 2019 (COVID-19) disease in at-risk groups such as patients with
chronic obstructive pulmonary disease (COPD) are poorly understood. Inhaled
corticosteroids (ICSs) are widely used in COPD, but the extent to which these therapies
protect or expose patients to risk of severe COVID-19 is unknown. Objective The aim of this
study was to evaluate the effect of ICSs following pulmonary expression of the SARS-CoV-2 …
Coronavirus disease 2019 (COVID-19) disease in at-risk groups such as patients with
chronic obstructive pulmonary disease (COPD) are poorly understood. Inhaled
corticosteroids (ICSs) are widely used in COPD, but the extent to which these therapies
protect or expose patients to risk of severe COVID-19 is unknown. Objective The aim of this
study was to evaluate the effect of ICSs following pulmonary expression of the SARS-CoV-2 …