[HTML][HTML] Human intrahepatic regulatory T cells are functional, require IL‐2 from effector cells for survival, and are susceptible to Fas ligand‐mediated apoptosis
Regulatory T cells (T reg) suppress T effector cell proliferation and maintain immune
homeostasis. Autoimmune liver diseases persist despite high frequencies of T reg in the
liver, suggesting that the local hepatic microenvironment might affect T reg stability, survival,
and function. We hypothesized that interactions between T reg and endothelial cells during
recruitment and then with epithelial cells within the liver affect T reg stability, survival, and
function. To model this, we explored the function of T reg after migration through human …
homeostasis. Autoimmune liver diseases persist despite high frequencies of T reg in the
liver, suggesting that the local hepatic microenvironment might affect T reg stability, survival,
and function. We hypothesized that interactions between T reg and endothelial cells during
recruitment and then with epithelial cells within the liver affect T reg stability, survival, and
function. To model this, we explored the function of T reg after migration through human …