Intrahepatic regulatory T cells in autoimmune hepatitis are associated with treatment response and depleted with current therapies
R Taubert, M Hardtke-Wolenski, F Noyan, A Wilms… - Journal of …, 2014 - Elsevier
Background & Aims Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease
usually requiring life-long immunosuppression. The mechanisms for disease initiation and
chronicity are largely unknown. A contribution of deficient regulatory T cells (Tregs) in the
blood was controversially discussed recently. So far investigations in the target organ have
been limited to single parameter analysis in untreated AIH. Methods We retrospectively
analysed the pattern of liver infiltrating T, B and regulatory T cells quantitatively with …
usually requiring life-long immunosuppression. The mechanisms for disease initiation and
chronicity are largely unknown. A contribution of deficient regulatory T cells (Tregs) in the
blood was controversially discussed recently. So far investigations in the target organ have
been limited to single parameter analysis in untreated AIH. Methods We retrospectively
analysed the pattern of liver infiltrating T, B and regulatory T cells quantitatively with …