Genetic predisposition and environmental danger signals initiate chronic autoimmune hepatitis driven by CD4+ T cells
M Hardtke-Wolenski, K Fischer, F Noyan, J Schlue… - Hepatology, 2013 - journals.lww.com
Autoimmune hepatitis (AIH) is defined as a chronic liver disease with loss of tolerance
against liver tissue eventually leading to cirrhosis if left untreated. 80%-90% of patients can
be treated with a life-long immunosuppression. Unfortunately, there are strong drug-related
side effects and steroid-refractory patients. Therefore, there is a need for a model system to
investigate the complex immunopathogenesis of this chronic disease and subsequently to
develop new therapeutic interventions. We developed a new model of experimental murine …
against liver tissue eventually leading to cirrhosis if left untreated. 80%-90% of patients can
be treated with a life-long immunosuppression. Unfortunately, there are strong drug-related
side effects and steroid-refractory patients. Therefore, there is a need for a model system to
investigate the complex immunopathogenesis of this chronic disease and subsequently to
develop new therapeutic interventions. We developed a new model of experimental murine …