[HTML][HTML] Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice
A Carambia, B Freund, D Schwinge, OT Bruns… - Journal of …, 2015 - Elsevier
Background & Aims It is well-known that the liver can induce immune tolerance, yet this
knowledge could, thus far, not be translated into effective treatments for autoimmune
diseases. We have previously shown that liver sinusoidal endothelial cells (LSECs) could
substantially contribute to hepatic tolerance through their ability to induce CD4+ Foxp3+
regulatory T cells (Tregs). Here, we explored whether the Treg-inducing potential of LSECs
could be harnessed for the treatment of autoimmune disease. Methods We engineered a …
knowledge could, thus far, not be translated into effective treatments for autoimmune
diseases. We have previously shown that liver sinusoidal endothelial cells (LSECs) could
substantially contribute to hepatic tolerance through their ability to induce CD4+ Foxp3+
regulatory T cells (Tregs). Here, we explored whether the Treg-inducing potential of LSECs
could be harnessed for the treatment of autoimmune disease. Methods We engineered a …