Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosis
WT Huang, H Akhter, C Jiang, M MacEwen… - Experimental …, 2015 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disorder with unknown cause and no
effective treatment. The incidence of and mortality from IPF increase with age, suggesting
that advanced age is a major risk factor for IPF. The mechanism underlying the increased
susceptibility of the elderly to IPF, however, is unknown. In this study, we show for the first
time that the protein level of plasminogen activator inhibitor 1 (PAI-1), a protease inhibitor
which plays an essential role in the control of fibrinolysis, was significantly increased with …
effective treatment. The incidence of and mortality from IPF increase with age, suggesting
that advanced age is a major risk factor for IPF. The mechanism underlying the increased
susceptibility of the elderly to IPF, however, is unknown. In this study, we show for the first
time that the protein level of plasminogen activator inhibitor 1 (PAI-1), a protease inhibitor
which plays an essential role in the control of fibrinolysis, was significantly increased with …