Obesity and mortality among patients diagnosed with COVID-19: results from an integrated health care organization
SY Tartof, L Qian, V Hong, R Wei… - Annals of internal …, 2020 - acpjournals.org
Annals of internal medicine, 2020•acpjournals.org
Background: Obesity, race/ethnicity, and other correlated characteristics have emerged as
high-profile risk factors for adverse coronavirus disease 2019 (COVID-19)–associated
outcomes, yet studies have not adequately disentangled their effects. Objective: To
determine the adjusted effect of body mass index (BMI), associated comorbidities, time,
neighborhood-level sociodemographic factors, and other factors on risk for death due to
COVID-19. Design: Retrospective cohort study. Setting: Kaiser Permanente Southern …
high-profile risk factors for adverse coronavirus disease 2019 (COVID-19)–associated
outcomes, yet studies have not adequately disentangled their effects. Objective: To
determine the adjusted effect of body mass index (BMI), associated comorbidities, time,
neighborhood-level sociodemographic factors, and other factors on risk for death due to
COVID-19. Design: Retrospective cohort study. Setting: Kaiser Permanente Southern …
Background
Obesity, race/ethnicity, and other correlated characteristics have emerged as high-profile risk factors for adverse coronavirus disease 2019 (COVID-19)–associated outcomes, yet studies have not adequately disentangled their effects.
Objective
To determine the adjusted effect of body mass index (BMI), associated comorbidities, time, neighborhood-level sociodemographic factors, and other factors on risk for death due to COVID-19.
Design
Retrospective cohort study.
Setting
Kaiser Permanente Southern California, a large integrated health care organization.
Patients
Kaiser Permanente Southern California members diagnosed with COVID-19 from 13 February to 2 May 2020.
Measurements
Multivariable Poisson regression estimated the adjusted effect of BMI and other factors on risk for death at 21 days; models were also stratified by age and sex.
Results
Among 6916 patients with COVID-19, there was a J-shaped association between BMI and risk for death, even after adjustment for obesity-related comorbidities. Compared with patients with a BMI of 18.5 to 24 kg/m2, those with BMIs of 40 to 44 kg/m2 and greater than 45 kg/m2 had relative risks of 2.68 (95% CI, 1.43 to 5.04) and 4.18 (CI, 2.12 to 8.26), respectively. This risk was most striking among those aged 60 years or younger and men. Increased risk for death associated with Black or Latino race/ethnicity or other sociodemographic characteristics was not detected.
Limitation
Deaths occurring outside a health care setting and not captured in membership files may have been missed.
Conclusion
Obesity plays a profound role in risk for death from COVID-19, particularly in male patients and younger populations. Our capitated system with more equalized health care access may explain the absence of effect of racial/ethnic and socioeconomic disparities on death. Our data highlight the leading role of severe obesity over correlated risk factors, providing a target for early intervention.
Primary Funding Source
Roche–Genentech.
acpjournals.org