Pre-operative determination of an individual's neutrophil response: a potential predictor of early cardiac transplant cellular rejection

A Soo, B Maher, J McCarthy, L Nölke, A Wood… - The Journal of heart and …, 2009 - Elsevier
BACKGROUND: Success of heart transplantation is affected by allograft rejection, which is
known as a lymphocyte-mediated process. Recent studies suggest that neutrophils
contribute to this process. We hypothesized that the severity of cardiac rejection can be
predicted by evaluating an individual's neutrophil transendothelial migration potential, which
can be assessed through artificial stimulation of neutrophils. METHODS: Eleven patients
were recruited from the active heart transplant list. Pre-operative blood samples were …