IL-25 induces M2 macrophages and reduces renal injury in proteinuric kidney disease
Q Cao, C Wang, D Zheng, Y Wang… - Journal of the …, 2011 - journals.lww.com
The kidney contains receptors for the cytokine IL-25, but the effects of IL-25 in CKD are
unknown. Here, we induced adriamycin nephropathy in both BALB/c mice and severe
combined immunodeficient (SCID) mice, and we injected IL-25 for 7 consecutive days
starting at day 5 after adriamycin administration. BALB/c mice treated with IL-25 had less
glomerulosclerosis, tubular atrophy, interstitial expansion, and proteinuria than control mice
at day 28. IL-25 increased the levels of IL-4 and IL-13 in serum, kidney, renal draining lymph …
unknown. Here, we induced adriamycin nephropathy in both BALB/c mice and severe
combined immunodeficient (SCID) mice, and we injected IL-25 for 7 consecutive days
starting at day 5 after adriamycin administration. BALB/c mice treated with IL-25 had less
glomerulosclerosis, tubular atrophy, interstitial expansion, and proteinuria than control mice
at day 28. IL-25 increased the levels of IL-4 and IL-13 in serum, kidney, renal draining lymph …