Increased ILC2s in the eosinophilic nasal polyp endotype are associated with corticosteroid responsiveness
Group 2 innate lymphoid cells (ILC2s) have recently been identified in human nasal polyps,
but whether numbers of ILC2s differ by polyp endotype or are influenced by corticosteroid
use is unknown. Here, we show that eosinophilic nasal polyps contained double the number
of ILC2s vs. non-eosinophilic polyps. Polyp ILC2s were also reduced by 50% in patients
treated with systemic corticosteroids. Further, using a fungal allergen challenge mouse
model, we detected greatly reduced Th2 cytokine-producing and Ki-67+ proliferating lung …
but whether numbers of ILC2s differ by polyp endotype or are influenced by corticosteroid
use is unknown. Here, we show that eosinophilic nasal polyps contained double the number
of ILC2s vs. non-eosinophilic polyps. Polyp ILC2s were also reduced by 50% in patients
treated with systemic corticosteroids. Further, using a fungal allergen challenge mouse
model, we detected greatly reduced Th2 cytokine-producing and Ki-67+ proliferating lung …
