[HTML][HTML] Increased innate type 2 immune response in house dust mite-allergic patients with allergic rhinitis

H Zhong, XL Fan, QN Yu, ZL Qin, D Chen, R Xu… - Clinical …, 2017 - Elsevier
Group 2 innate lymphoid cells (ILC2s) are essential in initiating and driving allergic immune
responses. However, there were inconsistent findings of the ILC2 levels in allergic rhinitis
(AR) patients. This study investigated the ILC2 levels in the peripheral blood of house dust
mite (HDM)-sensitized AR patients and their ability to secrete type 2 cytokines. The levels of
ILC2s with phenotypic ILC2 characteristics were increased in the HDM-AR patients. The AR
patients' symptom score and IL-13 levels were positively associated with the ILC2s in HDM …