Acute cellular rejection in small-bowel transplantation impairs NCR+ innate lymphoid cell subpopulation 3/interleukin 22 axis
MP Molineris, VG Polo, C Rumbo, C Fuxman… - Transplant …, 2020 - Elsevier
Acute cellular rejection (ACR) remains as one of the main causes of graft loss and death in
intestinal transplant (ITx) patients. ACR promotes intestinal injury, disruption of the mucosal
barrier, bacterial translocation, and organ dysfunction. As epithelial regeneration is critical in
reversing these consequences, the functional axis between the innate lymphoid cell
subpopulation 3 (ILC3) and interleukin 22 plays an essential role in that process. Natural-
cytotoxic-receptor–positive (NCR+) ILC3 cells have been demonstrated to induce intestinal …
intestinal transplant (ITx) patients. ACR promotes intestinal injury, disruption of the mucosal
barrier, bacterial translocation, and organ dysfunction. As epithelial regeneration is critical in
reversing these consequences, the functional axis between the innate lymphoid cell
subpopulation 3 (ILC3) and interleukin 22 plays an essential role in that process. Natural-
cytotoxic-receptor–positive (NCR+) ILC3 cells have been demonstrated to induce intestinal …