RORγt+ IL-22-producing NKp46+ cells protect from hepatic ischemia reperfusion injury in mice
E Eggenhofer, M Sabet-Rashedi, M Lantow… - Journal of …, 2016 - Elsevier
Background & Aims NKp46+ cells are major effector cells in the pathogenesis of hepatic
ischemia reperfusion injury (IRI). Nevertheless, the precise role of unconventional subsets
like the IL-22-producing NKp46+ cells (NK22) remains unknown. The purpose of this study
was to examine the role of NK22 cells in IRI in transplantation, particularly with respect to
regulation by the transcription factor ROR-gamma-t (RORγt). Methods To explore the role of
NK22 cells in IRI in the absence of adaptive immunity, B6. RORγt-gfp/wt-reporter and B6 …
ischemia reperfusion injury (IRI). Nevertheless, the precise role of unconventional subsets
like the IL-22-producing NKp46+ cells (NK22) remains unknown. The purpose of this study
was to examine the role of NK22 cells in IRI in transplantation, particularly with respect to
regulation by the transcription factor ROR-gamma-t (RORγt). Methods To explore the role of
NK22 cells in IRI in the absence of adaptive immunity, B6. RORγt-gfp/wt-reporter and B6 …
