IL-33 exacerbates acute kidney injury
A Akcay, Q Nguyen, Z He, K Turkmen… - Journal of the …, 2011 - journals.lww.com
Inflammation contributes to the pathogenesis of acute kidney injury (AKI). IL-33 is a
proinflammatory cytokine, but its role in AKI is unknown. Here we observed increased
protein expression of full-length IL-33 in the kidney following induction of AKI with cisplatin.
To determine whether IL-33 promotes injury, we administered soluble ST2 (sST2), a fusion
protein that neutralizes IL-33 activity by acting as a decoy receptor. Compared with cisplatin-
induced AKI in untreated mice, mice treated with sST2 had fewer CD4 T cells infiltrate the …
proinflammatory cytokine, but its role in AKI is unknown. Here we observed increased
protein expression of full-length IL-33 in the kidney following induction of AKI with cisplatin.
To determine whether IL-33 promotes injury, we administered soluble ST2 (sST2), a fusion
protein that neutralizes IL-33 activity by acting as a decoy receptor. Compared with cisplatin-
induced AKI in untreated mice, mice treated with sST2 had fewer CD4 T cells infiltrate the …