Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone
P Brazeau, W Vale, R Burgus, N Ling, M Butcher… - Science, 1973 - science.org
P Brazeau, W Vale, R Burgus, N Ling, M Butcher, J Rivier, R Guillemin
Science, 1973•science.orgA peptide has been isolated from ovine hypothalamus which, at 1× 10-9 M, inhibits secretion
in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in
rats. Its structure is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH. The
synthetic replicate is biologically active.
in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in
rats. Its structure is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH. The
synthetic replicate is biologically active.
A peptide has been isolated from ovine hypothalamus which, at 1 × 10-9M, inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats. Its structure is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH. The synthetic replicate is biologically active.
AAAS