[HTML][HTML] Cell survival during complete nutrient deprivation depends on lipid droplet-fueled β-oxidation of fatty acids
AG Cabodevilla, L Sánchez-Caballero, E Nintou… - Journal of Biological …, 2013 - ASBMB
Cells exposed to stress of different origins synthesize triacylglycerols and generate lipid
droplets (LD), but the physiological relevance of this response is uncertain. Using complete
nutrient deprivation of cells in culture as a simple model of stress, we have addressed
whether LD biogenesis has a protective role in cells committed to die. Complete nutrient
deprivation induced the biogenesis of LD in human LN18 glioblastoma and HeLa cells and
also in CHO and rat primary astrocytes. In all cell types, death was associated with LD …
droplets (LD), but the physiological relevance of this response is uncertain. Using complete
nutrient deprivation of cells in culture as a simple model of stress, we have addressed
whether LD biogenesis has a protective role in cells committed to die. Complete nutrient
deprivation induced the biogenesis of LD in human LN18 glioblastoma and HeLa cells and
also in CHO and rat primary astrocytes. In all cell types, death was associated with LD …